A high proportion of affected patients have variable degrees of disability after treatment. (C) 2010 Elsevier Inc. All rights reserved. Semin Arthritis Rheum 39:246-256″
“This review summarizes target populations of neonates for which erythropoietin (Epo) neuroprotective therapy might be of benefit, PCI-32765 price and the mechanisms by which Epo functions as a neuroprotective
agent. Potential risks of Epo are reviewed. Finally, the progression of Epo neuroprotection from preclinical studies to translational studies is discussed.”
“Objectives: This review examines the burden and patterns of disease in systemic lupus erythematosus (SLE) and the influence and interactions of gender, ethnicity, age, and psychosocial attributes with respect to disease
progression, focusing on issues relevant to clinical practice and research.
Methods: PubMed literature search complemented by review of bibliographies listed in identified articles.
Results: An increased risk among reproductive age women is clearly seen GSK1838705A in African Americans in the United States. However, in other populations, a different pattern is generally seen, with the highest age-specific incidence rates occurring in women after age 40 years. The disease is 2 to 4 times more frequent, and more severe, among nonwhite populations around the world and tends to be more severe in men and in pediatric and late-onset lupus. SLE patients now experience a higher than 90% survival rate at 5 years. The less favorable survival experience of ethnic minorities is possibly related to socioeconomic status rather than to ethnicity per se, and adequate social support has been shown to be a protective factor, in general, in SLE patients. Discordance between physician and patient ratings of disease activity may affect quality of care.
Conclusions: Our understanding of ways to improve outcomes in SLE patients could benefit from patient-oriented research focusing on many dimensions of disease
burden. Promising research initiatives include the inclusion Selleck Pfizer Licensed Compound Library of community-based patients in longitudinal studies, use of self-assessment tools for rating disease damage and activity, and a focus on self-perceived disease activity and treatment compliance. Published by Elsevier Inc. Semin Arthritis Rheum 39:257-268″
“Aim: To evaluate the relationship between arterial saturation values determined by pulse oximetry in the first weeks of life on the incidence of retinopathy of prematurity (ROP). Methods: Randomized and observational studies were sought that compare the incidence of ROP in babies with high or low oxygen saturation targeting assisted by pulse oximetry.