Importantly, these patients have a higher risk of lymphoma development (14% versus 1%).
Conclusions: Patients with GCs are characterized by more severe disease, although the small number of studies and their design hamper generalizability of results. The precise mechanisms that contribute to the development and persistence of germinal centers in pSS are largely unknown. This and
the strongly increased risk of lymphoma development warrant intensive studies CBL0137 nmr for the role of germinal centers in the immunopathology of pSS. (c) 2013 Elsevier Inc. All rights reserved. Semin Arthritis Rheum 42:368-376″
“The role of oxidized immunoglobulin G in type 1 diabetic smokers has been investigated in the present study. Human immunoglobulin G (IgG) was modified by reactive oxygen species (ROS). The binding characteristics of circulating autoantibodies in type 1 diabetes patients against native and modified IgG were assessed by direct binding ELISA. High degree of specific binding by 68.5% of patients sera towards ROS-modified IgG was observed in comparison to its native analogue (p < 0.05). In addition, diabetic smokers (n = 28) were examined and the results were compared with diabetic non-smokers (n = 26). Circulating antibodies of diabetic smokers showed
substantially stronger binding to modified IgG as compared with the antibodies present in diabetic non-smokers (p < 0.05). Normal human sera (n = 53) showed negligible binding with either 3-MA solubility dmso antigen. Competitive inhibition ELISA reiterates the direct binding results. The increase in total serum protein carbonyl levels in the diabetic smokers was largely due to an increase in oxidized IgG. Diabetic smokers showed substantially higher carbonyl contents in sera as well as in purified IgG as compared with sera and IgG of diabetic non-smokers. Collectively, the oxidation of plasma proteins, especially IgG, might enhance oxidative stress in type 1 diabetes smokers.”
“Background: Iraq used chemical weapons
extensively against the Iranians during the Iran-Iraq war (1980-1988). The aim of this study was to assess the health related quality of life (HRQOL) in people who had ophthalmologic complications due Lazertinib mouse to the sulfur mustard gas exposure during the war.
Methods: The Veterans and Martyrs Affair Foundation (VMAF) database indicated that there were 196 patients with severe ophthalmologic complications due to chemical weapons exposure. Of these, those who gave consent (n = 147) entered into the study. Quality of life was measured using the 36-item Short Form Health Survey (SF-36) and scores were compared to those of the general public. In addition logistic regression analysis was performed to indicate variables that contribute to physical and mental health related quality of life.
Results: The mean age of the patients was 44.8 (SD = 8.7) ranging from 21 to 75 years. About one-third of the cases (n = 50) reported exposure to chemical weapons more than once.