This prognostic

relationship appears to exist despite high pain and disability levels in the acute phase (lies et al 2008, lies et al 2009). However, evidence to support the premise that patients’ expectations predict the number of days absent from usual work is inconsistent (Schultz et al 2002, Schultz et al 2004, Dionne et al 2005, Heymans et al 2006, Du Bois et al 2009, Reme et al 2009). This inconsistency can be explained by variation in the methods used to assess the predictive VE-821 chemical structure relationship. Across studies there can be heterogeneity in the populations studied, the risk statistics reported, and the predictive measures considered. Even What is already known on this topic: Acute low back pain is common and it becomes Epacadostat nmr chronic in a small proportion of people. Some psychosocial factors measured in the acute or subacute stages of low back pain are predictors of progression to chronic low back pain. What this review adds: Adults with negative expectations about their recovery during acute or subacute low back pain are more likely to remain absent from

work more than 12 weeks after the onset of their pain, due to progression to chronic low back pain. Despite the inconsistencies in the evidence noted above, we aimed to draw a conclusion from the available evidence using meta-analysis about whether the recovery expectations of adults with acute or subacute non-specific low back pain are predictive of progressing to chronic low back pain that is severe enough Idoxuridine to cause ongoing absence from usual work activities. We also aimed to examine the homogeneity of the studies and

characteristics that may modify any predictive relationship. To do this, we sought to examine all primary data from prospective inception cohort studies of the recovery expectations of people with acute or subacute non-specific low back pain. Therefore, the research question for this systematic review was: Do negative expectations about recovery in adults with acute or subacute non-specific low back pain increase the odds of absence from usual work due to progression to chronic low back pain? Four electronic databases were searched: PubMed, MEDLINE, Modulators EMBASE and PEDro. The search terms included: low back pain, back pain, patient expectations, expectations about recovery, prognosis, prognostic, risk factors, risk, psychosocial, psychological, sick leave, sickness, absence, absenteeism, workers’ compensation, redress, cohort studies and longitudinal studies (see Appendix 1 on the eAddenda for the full search strategy.) The titles and abstracts of the retrieved publications were screened by two reviewers (JMH, MHGdeG) working independently to identify potentially eligible studies. Eligible studies were defined by the criteria in Box 1.