Women in the chronic distress group reported greater pessimistic outlook.
Conclusion: Optimism and better early post-operative treatment outcomes predicted resilience to distress. Pre-operative interventions helping women to establish a realistic expectation of treatment outcome may minimize disappointment with treatment outcome and resultant distress, whereas post-operative rehabilitation should focus on symptom management. Copyright (C) 2009 John Wiley & Sons, Ltd.”
“Purpose: To evaluate and compare the therapeutic efficacy of quetiapine in bipolar I
and II depression patients in the clinical setting.
Patients and methods: This was an 8-week, multicenter, open-label, observational study for bipolar depression. The dosage of quetiapine was flexible, and concomitant medications were permitted on clinician’s judgments. A total of 1097 patients were enrolled, and 764 bipolar depression patients who exhibited CHIR98014 good therapeutic compliance (>75% compliance rate) were analyzed.
Results: JNK-IN-8 concentration Clinical Global Impression-Bipolar scale and Montgomery-Asberg Depression Rating Scale scores were significantly improved
at weeks four and eight compared with the baseline scores. At the end of the 8-week study, the response rate was 58.9%, and the remission rate was 42.1%. However, there were no significant differences in the response and remission rates between bipolar I and II disorder (BD-I and BD-II) patients (response rate 60.1% versus 56.3%; remission rate 44.5% versus 37.0%). Montgomery-Asberg Depression Rating Scale score at baseline (beta=0.612, P<0.001), duration of current episode (beta=-0.152, P=0.001), and presence of remission on previous episode (beta=0.111, P=0.012) were significantly associated with improvements in depressive symptoms. Fatigue (16.0%), somnolence (14.9%), and manic/hypomanic switching (0.6% at week four, 0.3% at week eight) were observed throughout the study
period.
Conclusion: The results of this study suggest that quetiapine improves depressive symptoms in BD-I and selleck kinase inhibitor BD-II patients with a minimal incidence of manic switching. The therapeutic efficacy of quetiapine increased with time. Quetiapine could be an effective and safe modality for the treatment of BD-I and BD-II.”
“Objective: African-American men have an incidence rate of prostate cancer 60% higher than Caucasian men. Over one-quarter of men with prostate cancer experience significant distress, yet psychosocial research has rarely focused on African-American men. This study presents novel data on emotional well-being, distress, anxiety, and depression in African-American men with prostate cancer.
Methods: This archival research combined two databases (N = 385 and N = 367) comprised of 55 African-American men with prostate cancer. Quality of life was assessed with the Functional Assessment of Cancer Therapy, distress was measured with the Distress Thermometer, and anxiety and depression were measured with the Hospital Anxiety and Depression Scale.