Figure S4. All slices are displayed for the comparison of seed-based functional connectivity during loving kindness meditation for meditators greater than novices. Brain regions in yellow/hot show greater functional connectivity with the posterior cingulate cortex/precuneus during loving kindness meditation in meditators than novices (Ps < 0.05 FWE, Inhibitors,research,lifescience,medical cluster corrected; slices displayed left to right). Table S1. Brain regions showing less intrinsic connectivity during loving kindness meditation in meditators as compared to controls. Table S2. Brain regions showing greater

functional connectivity with the posterior cingulate cortex/precuneus during loving kindness meditation in novices as compared to meditators. Table S3. Brain regions showing greater functional connectivity with the posterior cingulate cortex/precuneus during loving kindness

meditation in meditators as compared to novices. Click here to view.(6.4M, tiff) Click here to view.(6.4M, tiff) Click here to view.(6.4M, tiff) Click here to view.(6.4M, Inhibitors,research,lifescience,medical tiff) Click here to view.(127K, docx)
Current radiologic methods for evaluating response to therapy in glioblastoma multiforme (GBM) rely largely on magnetic resonance imaging (MRI) and consist of assessing changes in tumor morphology and the degree and extent of contrast enhancement (e.g., Macdonald criteria) (Wen et al. 2010). However, the utility of Inhibitors,research,lifescience,medical such methodology is limited, as changes in tumor size can be slow relative Inhibitors,research,lifescience,medical to the timescale of the underlying molecular physiology. Moreover, the degree of contrast enhancement by a GBM can be influenced by several nontumor processes

including radiation necrosis (Hygino da Cruz et al. 2011). In tumors, the rate of spontaneous apoptosis is increased compared to normal tissue, and is often associated with tumor cell TSA HDAC concentration turnover (Meggiato et al. 2000). High baseline apoptotic indices in untreated tumors have been associated with both Inhibitors,research,lifescience,medical undifferentiated malignancies and lower survival rates (Meggiato et al. 2000). However, in tumors treated with effective cancer therapies (e.g., temozolomide chemotherapy, radiosurgery) size reduction has been associated with apoptosis (Witham et al. 2005; Fernandez-Luna 2007). Therefore, given the role of apoptosis in therapeutic response of tumors, serial assessment of tumor apoptotic state through in vivo positron emission tomography (PET) imaging unless is highly desirable (Blankenberg 2008). A promising class of tracers proposed for molecular imaging of apoptosis is a family of small molecules developed by Aposense Ltd. (Petach-Tikva, Israel), of which the PET ligand 18F-ML-10 is a member (Reshef et al. 2007). In vitro studies using tritiated ML-10 (3H-ML-10) have shown that 3H-ML-10 selectively targets cells undergoing apoptosis and is not taken up by necrotic cells (Cohen et al. 2009). As a PET tracer, 18F-ML-10 shows a desirable rapid clearance from blood through the kidneys, and exhibits high stability in vivo (Hoglund et al. 2011).