The Bland-Altman analysis showed excellent agreement between AFRNT and PRNT. AFRNT is a fully automatable high-throughput neutralisation assay, which can be performed with measles and other types of viruses, including wild-type strains. It is perfectly suited for epidemiological and vaccine studies. (C) 2011 Elsevier B.V. All rights reserved.”
“The important role of dopamine (DA) in mediating feeding behavior and the positive reinforcing effects of some drugs is well recognized. Less widely studied is how feeding conditions might impact the sensitivity of drugs acting on DA systems. Food restriction, for example, has often been the focus of aging and longevity studies; however,
other studies have demonstrated that mild ARN-509 research buy food restriction markedly increases sensitivity to direct- and indirect-acting DA receptor agonists. Moreover, it is becoming clear that not only NCT-501 the amount of food, but the type of food, is an important factor in modifying the effects of drugs. Given the increased consumption of high fat and sugary foods, studies are exploring how consumption of highly palatable food impacts DA neurochemistry and the effects of drugs acting on these systems. For example,
eating high fat chow increases sensitivity to some behavioral effects of direct- as well as indirect-acting DA receptor agonists. A compelling mechanistic possibility is that central DA pathways that mediate the effects of some drugs are regulated by one or more of the endocrine hormones (e.g. insulin) that undergo marked changes during food restriction or after consuming high fat or sugary foods. Although traditionally recognized as an important signaling molecule in regulating energy homeostasis, insulin can also regulate DA neurochemistry. Because direct- and indirect-acting DA receptor drugs are used therapeutically and some are abused, a better understanding of how food intake impacts response to these drugs would likely facilitate improved treatment of clinical disorders
and provide information PD184352 (CI-1040) that would be relevant to the causes of vulnerability to abuse drugs.
This article is part of a Special Issue entitled ‘Central Control of Food Intake’. (C) 2012 Elsevier Ltd. All rights reserved.”
“Over the past 30 years hemispheric asymmetries in speech perception have been construed within a domain-general framework, according to which preferential processing of speech is due to left-lateralized, non-linguistic acoustic sensitivities. A prominent version of this argument holds that the left temporal lobe selectively processes rapid/temporal information in sound. Acoustically, this is a poor characterization of speech and there has been little empirical support for a left-hemisphere selectivity for these cues. In sharp contrast, the right temporal lobe is demonstrably sensitive to specific acoustic properties.