The aims of this study http://www.selleckchem.com/products/bmn-673.html were to assess the clinical outcomes of ACA after endoscopic resection and identify risk factors of recurrence. Methods: From 2005 to 2011, patients who underwent endoscopic resection for ACA in Seoul National University Hospital were retrospectively reviewed. The primary outcomes were local recurrence and metachronous advanced neoplasm after the endoscopic resection for ACA. Results: A total of 1,206 cases of ACA detected in 917 patients were enrolled. Median follow-up duration was 28.5 months (12.8–51.7). Local recurrence and metachronous

advanced neoplasm occurred in 44 (3.6%) and 167 (13.8%) cases, respectively. Cumulative rates of local recurrence in cases with one and more than two categories of ACA were 2.2% and 7.6% at 3 years, respectively. Cumulative rates of metachronous advanced neoplasm in cases

with 3 or more adenomas and advanced adenomas were 19.4% and 23.6% at 3 years, respectively. Independent LY294002 risk factors of local recurrence were ACA with two or three categories and piecemeal resection. Independent risk factors of metachronous advanced neoplasm were male sex, 3 or more adenomas, and 3 or more of ACA. Conclusion: ACA with 2 or 3 categories could show higher local recurrence rate after the endoscopic resection than that in

ACA with 1 category, which suggests the novel risk stratification of ACA according to the number of categories at index colonoscopy. Key Word(s): 1. advanced colorectal adenoma; 2. endoscopic resection; 3. recurrence Presenting Author: HYE KANG KIM Additional Authors: DAE YOUNG CHEUNG, JAE HYUN SEO, MIN YOUNG JEONG, 上海皓元医药股份有限公司 HYUNG JUN CHO, IL KYU KIM, JIN IL KIM, SOO HEON PARK, JAE KWANG KIM Corresponding Author: HYE KANG KIM Affiliations: The Catholic University of Korea, The Catholic University of Korea, The Catholic University of Korea, The Catholic University of Korea, The Catholic University of Korea, The Catholic University of Korea, The Catholic University of Korea, The Catholic University of Korea Objective: The necessity of routine second look endoscopy (SLE) after endoscopic resection remains unclear. Methods: Records of patients who underwent endoscopic resection with or without SLE were reviewed retrospectively. The occurrence of delayed bleeding was measured as primary outcome. Results: A total of 218 patients were enrolled and 6 were excluded due to perforation during endoscopic resection. A total of 6 patients presented delayed bleeding in forms of hematemesis or melena. Delayed bleeding occurred at 6.