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angiogenic factors? Mol Cell Endocrinol 2007, 269 (1–2) : 65–80.CrossRefPubMed Competing www.selleckchem.com/products/H-89-dihydrochloride.html interests The authors declare that they have no competing interests. Authors’ contributions OA design and conception of the study, analysis of data, revision of the

manuscript, RMM acquisition and analysis of data, draft and revision of the manuscript, JAS acquisition of data, CVG critically revised the manuscript and also contributed to the analysis, AAS supervised the immunohistochemistry, revised the manuscript, JGCV checked the immunohistochemistry, revised the final version, EAO revised the data, ALG carried out the immunohistochemistry, MAJ critical revision of the manuscript and JLA conception of the study and revision of the manuscript. All authors have read and approved the final version of the manuscript.”
“Background Soft Tissue Sarcomas (STS) are malignant tumors that develop within mesenchymal connective tissue and can occur in any nearly part of the body, most commonly in the limbs, which represent over 45% of occurrences [1]. STS growth does not usually cause any noticeable symptoms in early stages, making early detection uncommon. Some STS such as synovial sarcoma, malignant fibrous histiocytoma, rhabdomyosarcoma and certain neurogenic sarcomas tend to invade peripheral tissues, such as nerves, vessels and bones, and are thus have a relatively poor prognosis and are difficult to cure [2]. The treatment of limb STS have traditionally included surgery, which can involve extensive muscle excision or resection [3].