The formulation was evaluated for

gelation temperature, gelation time, drug-polymer compatibility, drug content uniformity, viscosity, in vitro drug release profile and stability studies. The release of loaded Miconazole nitrate from the hydrogel was significantly sustained and the effect of PEG-4000 and Glycerophosphate concentration on release rate was observed. The results showed selleck products that the formed hydrogel is a controlled release carrier, which will favour its use as an improved vaginal drug delivery system.”
“To retrospectively evaluate the outcome of C1-2 transarticular screws combined with C1 laminar hooks fixation.

All patients underwent atlantoaxial fixation during a 5-year period. The surgical technique and treatment procedures were intensively reviewed Pictilisib and clinical symptoms, neurological function and imaging appearance were retrospectively evaluated.

The clinical and radiology follow-up indicated a stable arthrodesis and clinical relief from symptoms for all patients. All patients with neurological defects improved an average of 1.33 grade at their most recent clinical assessment, P < 0.05; their average admission ASIA motor score, pin prick score and light touch score improved to an average follow-up ASIA score of 99.80 (99.83 +/- A 0.38), 111.83 (111.83 +/- A 0.45), and

111.89 (111.89 +/- A 0.32), respectively. No neurovascular impairment and case of implant failure were observed.

The C1-2 transarticular screws combined with C1 laminar hooks fixation is a reliable technique for atlantoaxial instability.”
“The purpose of this study was to obtain information on the photochemical properties of ketoconazole, an antifungal agent. Photodegradation of ketoconazole in solution

and shampoo under exposure to UV-C (254 nm) and UV-A (352 nm) radiations as well as daylight was monitored by HPLC. Separation of ketoconazole from its degradation products was obtained with monoisopropylamine – methanol (2:500 v/v) and amonium acetate- water (1:200 w/v) (7:3 v/v) as mobile phase on a LiChrospher (R) 100 column RP-8, 5 mu m (150 mm x 4.6 mm) and a flow rate of 1 ml/min. The main protodegradation products: (cis-1-acetyl-4-4-[[2-(2-chlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenylpiperazine MK1775 and (cis-1-acetyl-4-4-[[2-(4-chlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl piperazine, were isolated and characterized by HPLC-MS and NMR spectrometry. The results indicated photodechlorination of ketoconazole when exposed to light and a significant decrease in antifungal activity.”
“In the present study, the bark ethanol extract of Maytenus guyanensis Klotzch (Celastraceae) was investigated for total phenol content, free radical scavenging (DPPH,ABTS, superoxide anion radical and singlet oxygen), antiinflammatory, antiplatelet and antiaggregating activities. M. guyanensis exhibited IC(50) 8.2 +/- 0.2, 28.4 +/- 0.7, 35.