An informed consent was obtained from all the patients, and the Ethics Committee of Yazd University of Medical Sciences approved the study. At the end of the trial, the gathered data were analyzed using SPSS 11.5 software and statistical tests (Chi-square, Mann-Whitney, Fisher, and Repeated Measure ANOVA tests).

A P<0.05 was considered statistically significant. Results The sodium valproate group comprised 11 men and 34 women at a mean±SD Inhibitors,research,lifescience,medical age of 31.3±3.5 years, and the Sumatriptan group consisted of 12 men and 33 women patients at a mean±SD age of 30.1±3.1 years. The groups had no significant difference based on sex (P=0.809). Table 1 shows the mean of headache severity before treatment as well as half an hour, one hour, and two hours after treatment in the sodium valproate and Sumatriptan groups, separately. Figure 2 demonstrates a comparison between the two drugs at the mentioned time points using the Repeated Measure ANOVA test. Table Inhibitors,research,lifescience,medical 1 Comparison of the effect of the drugs on reducing headache severity at similar time points Figure 2 Comparison the effect of the drugs on reducing headache severity at similar time points according to the Repeated Measure ANOVA test. Inhibitors,research,lifescience,medical V.S.: Valproate sodium; Sum.: Sumatriptan;

VNRS: Verbal Numerical Rating Scale In both groups, pain decrement at the mentioned time points compared to before injection was significant (P<0.001). Comparing these decrement rates in both groups at similar time points showed no significant difference, indicating the similar effect of sodium valproate and Sumatriptan on pain severity decrement. Inhibitors,research,lifescience,medical Table 2 depicts the rate of improvement in migraine-associated symptoms in the two groups and a comparison of these improvement rates between the two groups. According to this

table, photophobia, phonophobia, nausea, and vomiting were improved significantly in the sodium valproate group, while only photophobia and vomiting were decreased significantly in the Sumatriptan group, denoting the Selleckchem Mdm2 inhibitor advantage of sodium valproate in improving associated symptoms. Table 2 Comparison of the effect of the drugs on associated symptoms Inhibitors,research,lifescience,medical Table 3 illustrates the incidence rate of the side effects of the drugs in each group and a comparison of these rates between the two groups. The side effects of the drugs had been evaluated in the patients without the mentioned symptoms during before drug administration. For example, in the sodium valproate group, 28 patients had nausea initially and were, therefore, excluded before drug administration and the remaining 17 patients were followed up  for nausea; 5 of these 17 patients had nausea after drug administration. No patient in the two groups initially had facial paresthesia or hypotension and other symptoms such as vertigo and blurred vision. Table 3 shows that nausea, vomiting, facial paresthesia, and hypotension were more significantly frequent in the Sumatriptan group than in the sodium valproate group.