These guidelines had been tested for feasibility ( NVP-BGJ398 nmr Crompton et al 2001). The control group practised assisted overground walking. Aids such as knee splints, ankle-foot orthoses, parallel bars, forearm support frames and walking sticks could be used as part of the intervention. If a participant was too disabled to walk

with the help of a therapist, they practised standing and shifting weight and stepping forwards and backwards. Once participants could walk with the assistance of one therapist, they were instructed to increase their speed, and assistance from both the therapist and aids was reduced. Both groups underwent a maximum of 30 minutes per day of walking practice with assistance from one therapist, five days a week, until they achieved independent walking or were discharged from hospital. Other intervention Dactolisib datasheet involving the lower limbs (ie, strengthening exercises, practising activities such as sitting, standing up and standing) was standardised to a maximum of 60 min per day. No other part of the multidisciplinary

rehabilitation program was controlled. Therapists were provided with written guidelines describing progression and were trained in delivering both interventions. Information describing the specific features of the walking sessions such as treadmill speed and amount of weight support or use of aids, distance walked, and assistance required were recorded for each session. Adherence to the guidelines by therapists was enhanced by training, regular review of the recording sheets, and spot observations. Quality of walking was measured by quantifying speed (in m/s) and stride length (in cm) from a 10-m Walk Test. Participants were timed and the number of steps counted while walking at their comfortable speed over the middle 10 m of a 15 m track

to allow for acceleration and deceleration. Walking capacity was measured by quantifying the distance walked (in m) on a 6-min Walk Test. The instructions for the test were standardised according to Lipkin and colleagues (1986). Participants were instructed ‘Walk as far as possible in six minutes. You can slow down and rest if necessary but at the end of the L-NAME HCl six minutes you Modulators should aim to have been not able to have walked any further in the time period.’ No encouragement was given but the investigator informed participants at the half-way point (3 min) and when there was one minute remaining. Participants were allowed to wear shoes and use aids if necessary. Rests were permitted and recorded but the 6 min timer was not interrupted during rest periods. Walking perception, falls and community participation were measured using questionnaires. Walking was self-rated as a score out of 10.