However, even after the EORTC study, much PD0325901 remains to be clarified [4]. For example, because there are very few patients with pathologically proven lymph node metastasis, more extensive lymph node dissection might improve the outcome. Studies might be underpowered, and the therapeutic role of lymph node dissection in patients with high-risk tumors might be underestimated. In prostate cancer, the therapeutic significance of lymph node dissection in radical prostatectomy has not been established until now. However, several recent retrospective

studies have suggested that extensive lymph node dissection may have a significant impact on recurrence after radical prostatectomy [5]. In addition to the lack of robust randomized clinical trials in the literature, the boundaries of “extended” and “standard” pelvic lymph node dissection in radical prostatectomy need to be defined and standardized. Here we present four reviews, from experts in this field, on lymph node dissection in four

types of urologic cancers. We want our readers to understand the updated concepts of lymph node dissection of cancers of the kidney, bladder, upper urinary tract, and prostate gland. References 1. Dorin RP, Skinner EC (2010) Extended lymphadenectomy in bladder cancer. Curr Opin Urol 20:414–420PubMedCrossRef selleck products 2. Roscigno M, Shariat SF, Margulis V et al (2009) Impact of lymph node dissection on cancer specific survival in patients with upper tract urothelial carcinoma treated with radical nephroureterectomy. J Urol 181:2482–2489PubMedCrossRef 3. Blom JH, Mannose-binding protein-associated serine protease van Poppel H, Maréchal JM et al (2009) Radical nephrectomy with and without lymph-node dissection: final results of European Organization for

Research and Treatment of Cancer (EORTC) randomized phase 3 trial 30881. Eur Urol 55:28–34PubMedCrossRef 4. Culp SH, Wood CG (2009) Should patients undergoing surgery for renal cell carcinoma have a lymph node dissection? Nat Clin Pract Urol 6:126–127PubMedCrossRef 5. Hyndman ME, Mullins JK, Pavlovich CP (2010) Pelvic node dissection in prostate cancer: extended, limited, or not at all? Curr Opin Urol 20:211–217PubMedCrossRef”
“The Japan Society of Clinical Oncology produces an official journal, the International Journal of Clinical Oncology (IJCO). It is published in English, is widely indexed, and now has an impact factor of 1.508. Every day we receive many original articles submitted for LBH589 mouse publication in IJCO, but owing to page limitations, we must forgo publication of many good papers, including case reports.