Moderate associations between aromatic amine anticonvulsants and other HLA alleles have been proposed in Japanese patients. In contrast, HLA-B*5801 was found to be associated with allopurinol-induced cutaneous ADR, including SJS/TEN and DIHS/DRESS, in Caucasian and Asian patients, including the Japanese. These differences may, at least in part, be due to the differences in allele frequency in different ethnic populations. This article reviews the progress in pharmacogenomics, associated mainly with carbamazepine and allopurinol Androgen Receptor activity inhibition in different ethnic populations. Pharmacogenetic screening based on associations
between adverse reactions and specific HLA alleles helps to avoid serious
conditions associated with drug hypersensitivity.”
“To assess the role of electron microscopy in the evaluation of pediatric renal biopsies, all native kidney biopsies performed in children for nonneoplastic renal disease over a 2-year period were reviewed. Of 80 biopsies, the role of electron microscopy was classified as “”essential”" in 50 (63%), “”supportive or confirmatory”" in 18 (23%), and “”noncontributory”" in 9 (11%), with no glomeruli available for study in 3 (4%). The role of electron microscopy with respect to indication for biopsy and final diagnosis is discussed. This study confirms the continued importance of electron microscopy in the evaluation of pediatric renal biopsies.”
“Objective: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a clinical STAT inhibitor condition found in patients who have received intravenous or oral bisphosphonate therapy for various diseases related to bone. This report describes a novel treatment of BRONJ using autologous bone marrow stem cells, platelet-rich plasma, beta tricalcium phosphate,
and demineralized bone matrix.
Study Design: We report a 71-year-old woman with history of multiple myeloma treated with intravenous zoledronic acid during 4 years. After a tooth extraction, the patient presented Screening Library mw with a painful BRONJ lesion with no healing wound and cortical bone exposure. The patient was surgically managed with a standardized protocol of autologous stem cell therapy combining bone marrow harvest, cell concentration procedures, and intraoral surgery.
Results: CT scan performed 6 months later showed improvement of bone and concentric ossification. Cellular therapy might be considered a new strategy to heal BRONJ lesions.”
“Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe acute exfoliative skin diseases developing extensive epidermal detachment and mucosal damage. Although SJS and TEN are mostly caused by drugs, an animal model of TEN using drugs has not been established yet.