A retrospective interventional study, spanning 62 months, was undertaken at a tertiary eye care center situated in the southern region of India. A total of 256 eyes from 205 patients participated in the study, having given written informed consent. In all cases of DSEK, a single, experienced surgeon was the operator. Every donor dissection was performed using manual techniques. Inserted into the temporal corneal incision, the Sheet's glide held the donor button, placed with the endothelial side positioned downwards. A Sinskey's hook facilitated the insertion of the separated lenticule into the anterior chamber by pushing the lenticule directly into the chamber. Every complication, whether occurring during the operation or in the post-operative period, was documented and dealt with through medical or surgical remedies.
Prior to surgical intervention, the mean best-corrected visual acuity (BCVA) measured CF-1 m, subsequently enhancing to a postoperative value of 6/18. Donor graft perforations during intraoperative dissection were observed in 12 cases, along with thin lenticule formations in three eyes and a recurrence of anterior chamber (AC) collapse in three eyes. Among 21 eyes, lenticule dislocation was the most common complication, dealt with through the surgical procedures of graft repositioning and re-bubbling. Graft separation was minimal in eleven cases, and seven cases presented with interface haze. Following a partial release of the bubble, two cases of pupillary block glaucoma showed improvement and resolution. Management of surface infiltration in two cases involved the application of topical antimicrobial agents. The unfortunate occurrence of primary graft failure was observed in two instances.
While DSEK emerges as a hopeful alternative to penetrating keratoplasty for managing corneal endothelial decompensation, it inherently possesses both advantages and limitations, though the former often predominate over the latter.
DSEK, a potential alternative to penetrating keratoplasty for corneal endothelial decompensation, boasts both advantages and disadvantages, but the benefits typically exceed the limitations.

To analyze the impact of bandage contact lens (BCL) storage temperature – 2-8°C (cold BCLs, CL-BCLs) or room temperature (23-25°C, RT-BCLs) – on post-operative pain perception after photorefractive keratectomy (PRK) or corneal collagen crosslinking (CXL), in order to determine the related nociception factors.
In a prospective interventional study, 56 patients undergoing PRK for refractive correction, and 100 keratoconus (KC) patients undergoing CXL, were recruited after securing approval from the institutional ethics committee, and obtaining informed consent. Patients receiving bilateral PRK treatment were administered RT-BCL to one eye and CL-BCL to the other. On the initial post-operative day (PoD1), pain was evaluated employing the Wong-Baker FACES pain scale. Used bone marrow aspirates (BCLs) collected on the first postoperative day (PoD1) had their cellular content analyzed for the presence of transient receptor potential channels (TRPV1, TRPA1, TRPM8), calcitonin gene-related peptide (CGRP), and interleukin-6 (IL-6). A comparable quantity of KC patients, after CXL, were administered either RT-BCL or CL-BCL. presumed consent Pain assessment was conducted using the Wong-Baker FACES pain rating scale at the commencement of the post-operative period.
Pain scores, on Post-Operative Day 1 (PoD1), demonstrated a statistically significant reduction (P < 0.00001) in subjects treated with CL-BCL (mean ± standard deviation 26 ± 21) compared to those receiving RT-BCL (60 ± 24) following photorefractive keratectomy (PRK). In the clinical trial, CL-BCL treatment significantly reduced pain levels for 804% of the participating subjects. Among 196% of those evaluated, CL-BCL treatment demonstrated either no change or an augmentation of pain scores. A pronounced (P < 0.05) increase in TRPM8 expression was measured in BCL tissue of subjects reporting reduced pain following CL-BCL treatment, markedly contrasting the findings in those who did not. Subjects treated with CL-BCL (32 21) showed a substantially lower pain score on PoD1 (P < 0.00001) compared to the RT-BCL (72 18) group after the CXL procedure.
Post-operative pain reduction was substantially achieved through the simple method of applying a cold BCL, thereby potentially overcoming the pain-associated impediments to accepting PRK/CXL.
A markedly reduced pain response was observed following the use of a cold BCL post-operatively, potentially improving patient acceptance of PRK/CXL and negating the limitations imposed by post-operative discomfort.

Two years following small-incision lenticule extraction (SMILE) surgery, a comparative study of postoperative visual outcomes, including corneal higher-order aberrations (HOAs) and visual acuity, was performed on patients with an angle kappa greater than 0.30 mm who underwent angle kappa adjustment, versus eyes with an angle kappa less than 0.30 mm.
This retrospective study encompassed 12 patients undergoing the SMILE procedure for myopia and myopic astigmatism correction between October 2019 and December 2019. Each patient presented with one eye exhibiting a large kappa angle and the other eye a smaller kappa angle. A measurement of the modulation transfer function cutoff frequency (MTF) was executed by an optical quality analysis system (OQAS II; Visiometrics, Terrassa, Spain) twenty-four months after the surgical process.
The Strehl2D ratio, objective scatter index (OSI), and their corresponding values. The Tracey iTrace Visual Function Analyzer, version 61.0, from Tracey Technologies (Houston, TX, USA), was instrumental in evaluating HOAs. buy Unesbulin The quality of vision (QOV) questionnaire was employed to ascertain subjective visual quality.
Two years post-surgery, the average spherical equivalent (SE) refraction was -0.32 ± 0.040 for patients in the S-kappa group (kappa < 0.3 mm) and -0.31 ± 0.035 for the L-kappa group (kappa ≥ 0.3 mm). No statistically significant difference was observed (P > 0.05). Average OSI values were found to be 073 032 and 081 047, respectively; these values were not statistically significant (P > 0.005). A lack of meaningful distinction was observed in MTF.
The Strehl2D ratio's disparity between the two groups was not statistically significant (P > 0.05). No statistically significant differences (P > 0.05) were observed between the two groups regarding total HOA, spherical, trefoil, secondary astigmatism.
During SMILE, manipulating the kappa angle diminishes decentration, translating to fewer higher-order aberrations and enhanced visual performance. Genetic exceptionalism A dependable means of optimizing SMILE treatment concentration is offered by this approach.
In the SMILE procedure, modifying the angle kappa diminishes decentration, resulting in a reduction of high-order aberrations, and ultimately promotes enhanced visual acuity. For optimizing treatment concentration within SMILE, this method is a trustworthy option.

We seek to compare the visual efficacy of early enhancement post-surgery between small incision lenticule extraction (SMILE) and laser in situ keratomileusis (LASIK).
A review of eyes of patients who had undergone surgery at a tertiary eye care hospital between 2014 and 2020, and required early enhancement (within a year of their initial procedure), was performed. Measurements of epithelial thickness using anterior segment Optical Coherence Tomography (AS-OCT), corneal tomography, and refractive error stability were undertaken. Using photorefractive keratectomy, including a flap lift, the eyes were corrected after regression, with SMILE and LASIK having been the initial surgeries respectively. Pre- and post-enhancement measurements were performed on distance visual acuity, both corrected and uncorrected (CDVA and UDVA), along with mean refractive spherical equivalent (MRSE) and cylinder values. Statistical analysis with IBM SPSS software is a valuable asset for researchers.
The dataset comprised 6350 eyes that had undergone SMILE and 8176 eyes that had undergone LASIK, which were all included in the analysis. Following SMILE procedures, 32 eyes of 26 patients (5%) and, following LASIK procedures, 36 eyes of 32 patients (4.4%) underwent corrective enhancement surgery. Following the enhancement procedures of LASIK flap lift and SMILE PRK, UDVA logMAR values recorded were 0.02-0.05 and 0.09-0.16, respectively, displaying a statistically significant difference (P=0.009). An assessment of refractive sphere and MRSE revealed no substantial difference; the p-values for each were 0.033 and 0.009, respectively. Within the SMILE group, an impressive 625% of eyes reached a UDVA of 20/20 or better, contrasted with 805% in the LASIK group. A statistically significant difference was noted (P = 0.004).
PRK, implemented after SMILE, displayed comparable outcomes to LASIK with flap lift, showcasing a safe and effective method for early enhancement procedures following SMILE.
A PRK procedure performed after SMILE surgery demonstrated results comparable to those following a flap-lift LASIK, showcasing its safe and effective use for early enhancements after SMILE.

To measure the visual sharpness of two simultaneous soft multifocal contact lenses and compare the visual outcomes of multifocal lenses with their corresponding monovision adaptation in newly-fitted presbyopic patients.
A comparative, prospective study, double-masked, evaluated 19 participants who donned, in a random order, soft PureVision2 multifocal (PVMF) and clariti multifocal (CMF) lenses. Measurements were taken for visual acuity, encompassing high- and low-contrast distance vision, near vision acuity, stereopsis, contrast sensitivity, and glare visual acuity. With a multifocal and adjusted monovision lens design from one company, measurements were taken, subsequently replicated using a different company's lenses.
High-contrast distance visual acuity showed substantial differences between CMF (000 [-010-004]) and PureVision2 modified monovision (PVMMV; -010 [-014-000]) correction (P = 0.003), and also a significant discrepancy between CMF and clariti modified monovision (CMMV; -010 [-020-000]) correction (P = 0.002). The modified monovision lenses displayed a higher level of performance than CMF achieved. A statistically insignificant difference was found in the current study regarding contact lens corrections for low-contrast vision, near vision, and contrast sensitivity (P > 0.001).