PST is a three-phased treatment intended to be carried out in six sessions over 12 weeks.31 Mynors-Wallls31 explains

that the goal of phase 1 is linking symptoms to problems; phase 2 is clarifying and defining problems; and phase 3 is attempting to solve problems in a structured way. Phase 3 includes sessions focused on finding ways to address the problem and Rho inhibitor reviewing “homework assignments” related to the resolution of the problem, and sessions focused on reviewing how the problem was solved and generalizing the strategy to other problems the patient might wish to confront. Psychoiynamic interpersonal therapy PI therapy, originally Inhibitors,research,lifescience,medical termed Hobson’s conversational model of psychotherapy, was developed by Hobson8 and has been more recently studied by other investigators, most notably Guthrie and Shapiro. Guthrie9,10 describes PI as an integrative model of therapy that combines psychodynamic, humanistic, Inhibitors,research,lifescience,medical and interpersonal theory and

techniques. A typical course of PI is three to eight sessions. Unlike IPT, the primary tools of PI include transference and metaphors.32 Much like CBASP, the therapist-patient relationship is core to PI and important to the exploration of the connection between depressed mood and Inhibitors,research,lifescience,medical problematic interpersonal relationships. The therapist makes no assumptions concerning the patient’s problems or feelings, adopting a stance of individuality. Together, the therapist and client develop negotiation and communication skills. The goal of a PI therapist is to understand the patient’s personal, individual feelings concerning problems and the consequence or influence of these problems, and to offer Inhibitors,research,lifescience,medical interventions only in a tentative and nondogmatic way. Goals of treatment of unipolar disorders

In trying to understand the efficacy of psychotherapy, pharmacotherapy, combinations, and sequences, it is important to be clear about what the goals of treatment are in the management of unipolar disorders. Although nearly 50% to Inhibitors,research,lifescience,medical 60% of depressed outpatients will respond and experience a meaningful improvement in response to a first trial of antidepressant pharmacotherapy,33 only 1 in 3 patients will experience a full and complete remission of their symptoms and depressive episode.12 The goals of treatment should extend beyond response to a full and sustained remission the of symptoms and an improvement in psychosocial functioning.34 Ample evidence points to the negative consequences of treatments that fail to target such complete remission. Thase15 has demonstrated an increased recurrence risk for individuals who experience a partial remission, delayed response to acute treatment, return of symptoms during continuation treatment or within 1 year post-treatment, or residual symptoms post-treatment.