(see statement 23). CsA is usually ceased after 3–6 months of overlap with AZA/ 6-MP or methotrexate used as monotherapy after this time. Complications of CsA include hypertension, nephrotoxicity, seizure, gingival hyperplasia and hypertension. Both CsA and IFX can be used in IV-corticosteroid refractory UC and randomized comparative study of the two agents are in progress. Rescue treatment after failure of the first agent has a 33–40% chance of inducing remission with the second agent but at the risk of developing severe septic complications.136 Tacrolimus.  Tacrolimus has a greater potency, more predictable pharmacokinetic profile and better adverse effect profile than CsA.164 Tacrolimus has steroid-sparing

effects, is rapid in onset and colectomy can be averted in a proportion of UC patients. Ogata et al. conducted a placebo-controlled study in Japanese patients with refractory UC randomizing them to high-trough http://www.selleckchem.com/products/ly2157299.html levels of 10–15 ng/mL, low-trough levels of 5–10 ng/mL versus placebo and showed

that the clinical remission rates were 19%, 9% and 5%, respectively (P < 0.001). The clinical improvement rates at 2 weeks were 62%, 36%, and 10%, respectively. Colectomy was avoided in all patients.165 Overall, the long-term colectomy rate in another tacrolimus study was 22–34%. Adverse drug effects tend to be mild and include tremor, hyperglycemia, hypertension and infection.166,167 Toxic megacolon, non-responsiveness or drug-induced adverse effects to medical buy Talazoparib treatment, high-grade dysplasia, carcinoma, steroid dependency, massive bleeding, bowel perforation and failure to thrive in the pediatric patient are indications for surgery. Level of agreement: a-100%, b-0%, c-0%, d-0%, e-0% Quality of evidence: III Classification of recommendation: C Indications for surgery.  Surgery remains an important component in the treatment algorithm of UC and early colorectal surgery consultation is recommended especially for acute severe

UC that requires hospitalization. The decision to operate is best taken by the gastroenterologist and colorectal surgeon in conjunction with the patient.168 see more The type of surgery is dependent on the acuteness of the indication and the patient’s condition. Indications for surgery include toxic megacolon, non-responsiveness or drug-induced adverse effects to medical treatment, high-grade dysplasia, carcinoma, steroid dependency, massive bleeding, and failure to thrive in the pediatric patient are indications for surgery. Toxic megacolon is defined as total or segmental non-obstructive dilatation of the colon of at least 6 cm associated with systemic toxicity. This represents severe colitis and is associated with colonic perforation. Bowel perforation is the most serious of UC complications and is associated with high morbidity and mortality. Depending on the extent of disease, oral and/or per-rectal 5-aminosalylates help maintain remission.