Static cartilage models were created from high resolution threedimensional static MR data and accurately placed in their dynamic pose at each time frame based on the cine-PC (CPC) data. Cartilage contact parameters were calculated based on the surface overlap. Statistical analysis was performed using paired t-test and a one-sample repeated measures ANOVA. The sensitivity of the contact parameters to the known errors in the PF kinematics was determined.

Results: Peak mean PF contact area was 228.7 +/- 173.6 mm(2) at 40 degrees knee angle. During extension, contact centroid and peak strain locations tracked

medially on the femoral and patellar cartilage and were not significantly different from each other. At 25 degrees, 30 degrees, 35 degrees, and 40 degrees of knee extension, contact area was significantly different. Contact area and centroid selleckchem locations were insensitive to rotational and translational perturbations.

Conclusion: This study is a first step towards

unfolding the biomechanical pathways to anterior PF pain and osteoarthritis (OA) using dynamic, in vivo, and accurate methodologies. The database provides crucial data for future studies and for validation of, or as an input to, computational models. Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International.”
“The anti-inflammatory activity and the mechanism of action of Gentiana striata Maxim. has been investigated. NSC23766 mw The most active phase, the ethyl acetate extract of Gentiana striata Maxim. (EGS), displayed potent

inhibitory activity on feet oedema of rheumatoid arthritis (RA) inflicted rats. This anti-inflammatory activity might be partly based on the notable reduction of prostaglandin E2 (PGE(2)) and nitric oxide (NO) levels. Six further compounds isolated from EGS have previously been reported as having anti-inflammatory activity.”
“Objective: Osteoarthritis (OA) is a degenerative joint disease characterized by the progressive loss of articular cartilage. While macroscale degradation of the this website cartilage extracellular matrix (ECM) has been extensively studied, microscale changes in the chondrocyte pericellular matrix (PCM) and immediate microenvironment with OA are not fully understood. The objective of this study was to quantify ostearthritic changes in the micromechanical properties of the ECM and PCM of human articular cartilage in situ using atomic force microscopy (AFM).

Method: AFM elastic mapping was performed on cryosections of human cartilage harvested from both condyles of macroscopically normal and osteoarthritic knee joints. This method was used to test the hypotheses that both ECM and PCM regions exhibit a loss of mechanical properties with OA and that the size of the PCM is enlarged in OA cartilage as compared to normal tissue.