The main conclusion of this research is as follows: FBG2 gene can significantly promote the growth buy C59 wnt and proliferation of gastric cancer cells and normal gastric cells and change the cell cycle of them. There were still many deficiencies in our research. For example, only a few cell lines were used. In future researches, the cell lines with high expression of FBG2 gene will be used for RNAi or antisense and ribozyme expression inhibition in order to further verify the functions. Our extensive attempts are to find the capital ligands and functional route of FBG2 by proteomics and immunological methods. In addition,
animal experiments will also be used to indepthly investigate the relation between FBG2 gene (even the whole F-BOX family and the metabolic system of ubiquitin) and the occurrence and development of gastric cancer. Conclusion The results of the present investigation demonstrated that FBG2 gene is not expressed in MKN45 or HFE145 cell lines. The overexpression of the gene can influence some biological characteristics of gastric cancer cell or normal gastric cell. FBG2 can promote the growth and proliferation of these cells and help tumor cell maintain malignant phenotype. But it can have a negative influence on the apoptosis or the ability of invasion of gastric cancer cells. Acknowledgements The authors wish to thank Drs Wang gangshi and Yang shaobo, and
Nurse You Weidi, Wang weihua et al, for handling patient see more contacts. We wish to thank the Forth Military Medical University of PLA for providing means for the current investigation. References 1. Ilyin GP, Sérandour AL, Pigeon
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