This is a small series and ideally a larger cohort of patients would be desirable. Table 1. Linear Regression PVP: portal venous pressure, measured in mmHg. Disclosures: The following people have nothing to disclose: Ernest Hidalgo, Itxarone Bilbao, Jose Luis Lazaro, Liuis Castells, Ramon Chamco Study Aims Variceal

bleeding carries an inherent high risk of mortality. This aim of this study is to evaluate existing scoring Small molecule library screening systems for cirrhosis and upper gastrointestinal bleeding in predicting mortality. Methods All adult patients with varices noted on oesophageoduodenoscopy (OGD) for the indications of coffee-grounds vomitus, hematemesis or melena at a university hospital over an 18-month period were enrolled. The data was prospectively collected, and the variables for the Childs-PughTurcotte Score (CPT), Model for End-Stage Liver Disease (MELD) score, Glasgow-Blatchford score (GBS) and Rockall

scores (RS) were evaluated. Results A total of 73 patients fulfilled the criteria in the study period. The inpatient hospital mortality for this group was 13.7%. Using a univariate analysis, PKC inhibitor mortality was associated with the following variables: albumin less than 28 g/L (Odds Ratio 8.00 CI: 1.55-41.1, P = 0.011), Sclareol International Normalised Ratio (INR) more than 1.5 (Odds Ratio 4.41 Cl: 1.10-17.6 P = 0.057), and number of pints of blood transfused (P = 0.015) were associated with higher mortality. A logistic regression model incorporating

these variables had an area under the curve of 0.818. The following were significantly associated with mortality: CPT score >=10 (Odds Ratio 4.72 CI: 1.17-19.2, P = 0.035), MELD >=18 (Odds Ratio 7.95 Cl: 1.89-33.3, P = 0.006), Rockall Score >= 8 (Odds Ratio 14.3 Cl: 3.12-65.1, P = 0.001). Using a receiver operator characteristic analysis (ROC), the area under the curve (AUROC) was 0.726 for the CPT, 0.690 for the MELD, 0.728 for the GBS and 0.741 for the Rockall score. A logistic regression model using a combination of Rockall Score>=8, INR>=1.5 and Alb =<28 g/L had a superior AUROC compared to existing scoring systems, with an AUROC of 0.899 Conclusion CPT >=10, MELD >=18 and Rockall score >=8 were significantly correlated with mortality in variceal bleeding. A combination of Rockall Score, INR and Albumin was superior in predicting mortality in variceal bleeding compared with existing scores.