This review aims to update the current knowledge regarding the differential effects of polyphenols on PCD pathways and discuss Navitoclax their putative neuroprotective
action resulting from their capacity to modulate these pathways.”
“Background: Pneumonia is a leading cause of illness and death in young children. Interventions to improve case management of pneumonia are needed.
Objective: Our objective was to measure the effect of zinc supplementation in children with pneumonia in a population in which zinc deficiency is common.
Design: In a double-blind, placebo-controlled clinical trial, children aged 2-35 mo with severe (n = 149) or nonsevere (n = 2479) pneumonia defined according to criteria established by the World Health Organization were randomly assigned to receive zinc (10 mg for children aged 2-11 mo, 20 mg for children aged >= 12 mo) or placebo daily for 14 d as an adjuvant to antibiotics. The primary outcomes were treatment failure, defined as a need for change in antibiotics or hospitalization, and time to recovery from pneumonia.
Results: One of 5 children did not respond adequately GW786034 nmr to antibiotic treatment; the odds ratios between zinc and placebo
groups for treatment failure were 0.95 (95% CI: 0.78, 1.2) for nonsevere pneumonia and 0.97 (95% CI: 0.42, 2.2) for severe pneumonia. There was no difference in time to recovery between zinc and placebo groups for nonsevere (median: 2 d; hazard ratio: 1.0; 95% CI: 0.96, 1.1) or severe (median: 4 d; hazard ratio: 1.1; 95% CI: 0.79, 1.5) pneumonia. Regurgitation or vomiting <= 15 min after supplementation was observed more frequently among GSK621 children in the zinc group than among those in the placebo group during the supplementation period (37% compared with 13%; odds ratio: 0.25; 95% CI: 0.20, 0.30).
Conclusion: Adjuvant treatment with zinc neither reduced the risk of treatment failure nor accelerated
recovery in episodes of nonsevere or severe pneumonia. This trial was registered at clinical-trials.gov as NCT00148733. Am J Clin Nutr 2010;91:1667-74,”
“Frontal lobe seizures have a tendency to occur from sleep, and in some cases occur exclusively (or almost exclusively) from sleep; these individuals are said to have nocturnal frontal lobe epilepsy (NFLE). NFLE can be difficult to distinguish clinically from various other sleep disorders, particularly parasomnias, which also present with paroxysmal motor activity in sleep. Here, the manifestations of frontal lobe epilepsy are reviewed in detail, with particular reference to the influence of sleep and the characteristics of NFLE. Key aspects of differential diagnosis are also considered, and the underlying mechanisms involved in NFLE discussed.”
“Alzheimer’s disease (AD) brain is characterized by amyloid beta-peptide (A beta) deposits, neurofibrillary tangles, synapse loss, and extensive oxidative stress.