sponge and vector mediated miRNA replacement technologies offer more benefits for their use in scientific research whereas the use of small RNA or order Clindamycin compounds for miRNA repression or replacement is more promising from the perspective of healing miRNAs. In finish, solving the supply problem is of major interest for the clinical application of miRNA in disease treatment. Alternately, reversal of methylation connected miRNA silencing by DNA demethylating agents such as 5 aza 20 deoxycytidine could restore indigenous miRNA expression patterns. This substance in addition has been shown to induce autophagy, senescence, differentiation and apoptosis. Given the contribution of miRNAs in most of these biological processes, these results could be mediated by restoring miRNA term through DNA demethylation. The bioavailability, beneficial benefits, toxicity and negative effects of systemic distribution of miRNA analogues or DNA demethylation induced miRNA phrase must be carefully examined. Since no RNA disturbance based drugs have already been accepted as yet by the Food and Drug Administration available, the usage of miRNA analogues is limited to research purposes and may possibly never go beyond research. In 2007, Newman and Cragg updated their 2003 publication where they described the recently found anti cancer drugs of the previous few decades. They mentioned approximately 155 FDA-APPROVED anti cancer agencies, of which approximately 34% were of natural origin or directly based on products of natural origin. A number of these anti cancer drugs have an effect on cell cycle or cell proliferation and/or induce cell death Urogenital pelvic malignancy pathways. Because of the large regulatory potential and the crucial role of miRNA alterations in carcinogenesis, it is of critical interest to identify natural materials that affect miRNA expression and consider their anti cancer and cancer prevention activities. Accordingly, the impact of natural compounds on miRNA appearance can raise the awareness of cancer cells to mainstream chemotherapeutic agents and thus improve cancer treatment. In this section, we summarize experimental evidence showing the result of nutritional agents on miRNA modulation, that might contribute to their chemopreventive potential. The variable goal drug curcumin is removed from AZD5363 the rhizome of Curcuma longa. Its powerful therapeutic anti carcinogenic potential has received much consideration, and curcumin is being tested in clinical studies for colorectal, rectal and pancreatic cancer and for multiple myeloma, adenocarcinoma and osteosarcoma. Furthermore, curcumin is a negative regulator of inflammation, detox and metastasis pathways. In comparison, curcumin triggers CDKN2A and TP53 gene expression, resulting in cell cycle arrest and apoptosis and autophagy, respectively. An initial study by Sun et al.