One reason for this is that although these organelles are inherent to all cells, drugs are being developed that selectively
target the mitochondria of malignant cells without adversely affecting those of normal cells. Such anti-cancer drugs destabilize cancer cell mitochondria and these compounds are referred to as mitocans, classified into several groups according to their mode of action and the location or nature of their specific drug targets. Many mitocans selectively interfere with the bioenergetic functions of cancer cell mitochondria, causing major disruptions often associated with ensuing overloads in ROS production leading to the induction of the intrinsic ATG-010 apoptotic pathway. This in-depth review describes the bases for the bioenergetic differences found between normal and cancer Tariquidar cell mitochondria, focussing on those essential changes occurring during malignancy that clinically may provide the most effective targets for mitocan development. A common theme emerging is that mitochondrially mediated ROS activation as a trigger for apoptosis offers a powerful basis for cancer therapy. Continued research in this area is likely to identify increasing numbers of novel agents that should prove highly effective against a variety of cancers with preferential toxicity towards malignant tissue, circumventing tumor resistance to the other more established therapeutic
anti-cancer approaches. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.”
“Silver nanoparticles were coated onto cotton fabrics with 3-mercaptopropyltrimethoxysilane (3-MPTMS). The coating process was accomplished by soaking the cotton fabrics into silver colloid/3-MPTMS solution at 43 degrees C for 90 min. The coated fabrics were characterized by scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), and thermogravimetric analysis (TGA). SEM images showed a layer of silver nanoparticles and 3-MPTMS on cotton. The XPS data showed that distinguishable binding energy peaks of Ag 3d, Si 2p, Si 2s, S 2p
were 368/374, 102, 153, and 162 eV, respectively, which confirms the existence of silver and 3-MPTMS on cotton fabrics. The treated cotton fabrics showed prominent antimicrobial effectiveness against Staphylococcus learn more aureus (ATCC 6538) and Klebsiella pneumonia (ATCC 4352). Furthermore, the laundry test showed that 66% of silver nanoparticles were retained after five washing cycles. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 119:2261-2267, 2011″
“Based on semiempirical generalized embedded atom method (GEAM), we carried out molecular dynamics and Monte Carlo simulations to study the structural properties of FeCo and FeNi nanoparticles. It is found that these two kinds of nanoparticles possess a new stable quasicore-shell structure, no matter whether they are in molten or condensed state and whether they are prepared by annealing or quenching.