The prognosis

of patients with DCM has been very poor, and although there have been advances in the medical and device therapy for DCM in the last two decades, the condition still carries poor long-term prognosis with a median survival of two years after diagnosis3 and it appears to be related to the severity of left ventricular dysfunction and biventricular involvement in the disease process rather than secondary to pulmonary hypertension.4 The role of echocardiography is essential in not only establishing the diagnosis, but also in defining the aetiology, and understanding the pathophysiology.5 Using conventional echocardiography and Doppler ultrasound in a thorough, comprehensive SB431542 cell line and quantitative manner and using tissue-Doppler imaging, strain analysis, and real-time 3D echocardiography, it is possible to provide important pathophysiological information that can be used to guide the optimal clinical management of patients with DCM. Medicinal plants has been a major source of therapeutic potential since ancient times. Nowadays, there is an increase in the use of herbal plants based

medicines in rural as well as urban areas which is growing at a rate of 7–15% annually. Since 1980, the World Health Organization PI3K Inhibitor Library supplier has been encouraging developing countries to identify and exploit traditional medicine and phytotherapy. The evaluation of new drugs especially the phytochemically obtained materials has opened a vast area for research and helpful in making a transition from traditional to modern medicine in India. As per WHO, about 80% of the population in the world relies on the traditional medicine for the treatment of various diseases. Therefore, the evaluation of rich heritage of traditional medicine has become essential.6 and 7 In this regard, one such plant is Terminalia arjuna has been used in our Ayurvedic system of medicine since ages. The bark are used

as astringent, cooling, aphrodisiac, cardiotonic, in fractures, ulcers, spermatorrhoea, leucorrhoea, Thalidomide diabetes, cough, tumour, excessive perspiration, asthma, inflammation as well as skin disorders. 8 and 9 A lot of research has been done in cardiovascular field but only to explore its effect on chronic stable angina, endothelial dysfunction, heart failure, antihypertrophic and ischaemic mitral regurgitation and most of these effects have been seen in animal models. However effects on the echocardiographic parameters in patients with dilated cardiomyopathy which is common in India with systolic and with or without diastolic dysfunction has been extensively reported in this study for the first time. Arjunolic acid, a new triterpene and a potent extract from the bark of T. arjuna, has been shown to provide significant cardiac protection as it increases the levels of powerful antioxidants such as superoxide dismutase, catalase, glutathione, alpha-tocopherol, and ascorbic acid and many more cardioprotective effects.